This procedure uses the iTrack™ 250A Canaloplasty Microcatheter for 360-degree catheterization and viscodilation of Schlemm’s canal and the placement of a tensioning suture.
- Effectively revitalize aqueous outflow
- Perform a minimally invasive procedure that doesn’t require a bleb1
- Provide sustained reduction in IOP1
- Reduce patient dependence on medications1
- Provide an efficacious alternative treatment for open-angle patients refractory or intolerant to medications who are not yet ready for traditional surgery1
- Provide an improved safety profile with few intraoperative and postoperative complications in comparison with other glaucoma surgeries1
Click to view an animation of the iCath™ Canaloplasty procedure.
Results from multicenter, prospective clinical studies show the efficacy of Canaloplasty.1,2,3
- Trabeculectomy hypotony incidence is reported to be between 10% and 37%, and hyphema incidence is between 8% and 42%.4-7
In addition, when combined with cataract surgery, canaloplasty has resulted in both a 44% IOP reduction from 24.4 mmHg to 13.7 mmHg, and a mean medication reduction from 1.5 to 0.2 at 12 months.3
Current glaucoma treatment includes pharmaceutical regimens and penetrating surgical procedures have not demonstrated an ability to restore the natural drainage process. Instead, they attempt to:
- Reduce the production of intraocular fluid
- Enhance the secondary drainage pathway (uveoscleral)
- Create an artificial drainage pathway for fluid drainage (filtering blebs, tube shunts)
- Typically lowers IOP to 17 mmHg
- 42% of all pharmaceutically treated patients are on multiple medications
- One-third of all patients taking multiple medications are not compliant
- Can result in scarring
- A half-hour trabeculectomy may need 20 hours or more of postoperative follow-up to address complications
- 21% of all surgically treated patients experience complications
- 58% of all cases significantly regress over a 10-year period
- Lewis RA, von Wolff K, Tetz M, et al. Canaloplasty: circumferential viscodilation and tensioning of Schlemm’s canal using a flexible microcatheter for the treatment or open-angle glaucoma in adults. Interim clinical study analysis. J Cataract Refract Surg. 2007;33(7):1217-1226.
- Data on file. iScience Interventional Inc.
- Shingleton B, Tetz M, Korber N. Circumferential viscodilation and tensioning of Schlemm’s canal (canaloplasty) with temporal clear corneal phacoemulsification cataract surgery for open-angle glaucoma and visually significant cataract: one-year results. J Cataract Refract Surg. 2008;34:433-440.
- Gedde SJ, Herndon LW, Brandt JD, et al. Surgical complications in the tube versus trabeculectomy study during the first year of follow-up. Am J Ophthalmol. 2007;143:23-31.
- Scott IU, Greenfield DS, Schiffman J, et al. Outcomes of primary trabeculectomy with the use of adjunctive mitomycin. Arch Ophthalmol. 1998;116:286-291.
- Jampel HD, Musch DC, Gillespie BW, et al. Perioperative complications of trabeculectomy in the CIGTS. Am J Ophthalmology. 2005;140:16-22.
- Edmunds B, Thompson JR, Salmon JF, Wormald RP. The National Survey of Trabeculectomy. III. Early and late complications. Eye. 2002;16:297-303.
Return to top